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Published on: August 30, 2019
Rapidly progressing malignant insulinoma presented with multiple liver metastases: a case report
Askin Erdogan1, Erdogan Askin, Fatih Kose
1Departments of Gastroenterology, Baskent University, Ankara, Turkey.
Journal of Gastrointestinal Cancer
|April 27, 2010
Summary
A case of insulinoma with liver metastases showed that tumor biology may differ from histology. Platin-based chemotherapy offered benefits in diazoxide- and octreotide-resistant cases.
Area of Science:
- Oncology
- Endocrinology
- Pathology
Background:
- A 51-year-old female presented with hypoglycemia and loss of consciousness.
- Diagnostic workup revealed a pancreatic mass with liver metastases, identified as differentiated neuroendocrine carcinoma.
Observation:
- The patient experienced severe hypoglycemia due to hyperinsulinism (insulin level 55 IU/L, blood glucose 33 mg/dL).
- Initial treatment with diazoxide and chemotherapy stabilized glucose levels for over 4 months.
Findings:
- Despite initial stabilization, the neuroendocrine carcinoma progressed, leading to patient death 8 months after diagnosis.
- This case highlights a potential discrepancy between the biological behavior and histological classification of insulinoma.
Implications:
- Platin-based chemotherapy may offer a therapeutic option for patients with diazoxide- and octreotide-resistant insulinoma.
- Understanding the biological behavior of neuroendocrine tumors is crucial for effective treatment strategies.