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Related Experiment Video

Updated: Jun 13, 2026

Supramaximal Intensity Hypoxic Exercise and Vascular Function Assessment in Mice
10:00

Supramaximal Intensity Hypoxic Exercise and Vascular Function Assessment in Mice

Published on: March 15, 2019

Acetazolamide and exercise hypoxia.

J E Lafleur1, D Bartniczuk, A Collier

  • 1Department of Emergency Medicine, Alpert Medical School of Brown University, Providence, RI 02903, USA. johnelafleur@gmail.com

International Journal of Sports Medicine
|April 27, 2010
PubMed
Summary
This summary is machine-generated.

Stopping acetazolamide (a high-altitude acclimatization drug) can negatively impact exercise oxygenation. The effect depends on how long the drug is taken and the altitude reached.

Related Experiment Videos

Last Updated: Jun 13, 2026

Supramaximal Intensity Hypoxic Exercise and Vascular Function Assessment in Mice
10:00

Supramaximal Intensity Hypoxic Exercise and Vascular Function Assessment in Mice

Published on: March 15, 2019

Area of Science:

  • Physiology
  • Altitude Medicine
  • Pharmacology

Background:

  • Acetazolamide aids high-altitude acclimatization.
  • Optimal duration and effects of stopping acetazolamide are not well-understood.

Purpose of the Study:

  • To investigate the impact of acetazolamide cessation on exercise oxygenation.
  • To determine how altitude and duration of use influence these effects.

Main Methods:

  • Three groups were studied at different altitudes (4,060m, 4,120m, 4,770m) and acclimatization durations (7 days, 14 days).
  • Acetazolamide was administered and then stopped on specific days.
  • Standardized exercise oximetry was performed daily.

Main Results:

  • Stopping acetazolamide negatively affected exercise oxygenation (p=0.028).
  • At 4,100m, cessation after 1 week caused an 11% drop in oxygenation (p=0.008).
  • At 4,770m, cessation increased exercise oxygenation by 7% (p=0.027).

Conclusions:

  • Exercise oxygenation after stopping acetazolamide is influenced by acclimatization duration and altitude.
  • The findings highlight the complex physiological response to acetazolamide withdrawal at varying altitudes.