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Related Experiment Video

Updated: Jun 13, 2026

Injection of Porcine Adipose Tissue-Derived Stroma Cells via Waterjet Technology

Injection of Porcine Adipose Tissue-Derived Stroma Cells via Waterjet Technology

Published on: November 23, 2021

Stem cell therapy for stress urinary incontinence.

Dmitriy Nikolavsky¹, Michael B Chancellor

¹Department of Urology, William Beaumont Hospital, Royal Oak, Michigan, USA.

Neurourology and Urodynamics

|April 27, 2010

Summary

Stem cell therapy shows promise for stress urinary incontinence (SUI). Muscle-derived stem cells (MDSCs) may regenerate the urethral rhabdosphincter and improve muscle and nerve integration for better continence.

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Isolating Stem Cells from Soft Musculoskeletal Tissues

Isolating Stem Cells from Soft Musculoskeletal Tissues

Published on: July 5, 2010

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Isolating Stem Cells from Soft Musculoskeletal Tissues

Isolating Stem Cells from Soft Musculoskeletal Tissues

Published on: July 5, 2010

Area of Science:

Regenerative Medicine
Urology
Cellular Therapy

Background:

The rhabdosphincter in the mid-urethra is essential for urinary continence.
Stress urinary incontinence (SUI) significantly impacts quality of life.

Purpose of the Study:

To review the application of cellular therapy for SUI.
To present our experience with developing muscle-derived stem cells (MDSCs) for SUI treatment.

Main Methods:

Review of existing literature on stem cell therapy for SUI.
Development and preclinical assessment of muscle-derived stem cells (MDSCs).

Main Results:

Stem cells transplanted into the rhabdosphincter may promote regeneration.
Trophic factors released by stem cells can aid muscle and nerve integration.

Conclusions:

Cellular therapy, particularly with MDSCs, offers a potential therapeutic strategy for SUI.
MDSCs hold promise for augmenting rhabdosphincter function and restoring continence.