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Published on: April 19, 2022
Hepatocellular adenoma: a case report
Pattana Sornmayura1, Suvipaporn Siripornpitak, Surasak Leela-udomlipi
1Department of Pathology Faculty of Medicine, Ramathibodi Hospital, Mahidol University, Bangkok, Thailand.
Summary
Hepatocellular adenoma (HCA) can occur in women without oral contraceptive use. This case highlights HCA in a potential organ donor, emphasizing the need for awareness beyond typical risk factors.
Area of Science:
- Hepatology
- Oncology
- Genetics
Background:
- Hepatocellular adenoma (HCA) is a rare liver tumor primarily affecting women of reproductive age.
- While often associated with oral contraceptive use, non-contraceptive-associated cases are recognized.
- Understanding HCA variants is crucial for diagnosis and management.
Observation:
- A 26-year-old woman, a potential kidney donor, presented with a 4.1 cm hypervascular liver mass.
- Imaging revealed a lesion in liver segment V; laboratory tests showed normal liver enzymes and negative viral markers.
- The patient denied oral contraceptive pill usage.
Findings:
- Surgical resection (wedge resection of segment V) was performed with an uneventful recovery.
- Molecular studies identified three HCA variants based on HNF1A and beta-catenin gene mutations.
- Histological correlation proved challenging due to overlapping features between variants.
Implications:
- This case underscores that hepatocellular adenoma can occur independently of oral contraceptive use.
- Awareness of HCA in potential organ donors is important for recipient safety.
- Further research into HCA variants and diagnostic criteria is warranted.
