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Updated: Jun 13, 2026

Direct Drug Delivery to Kidney via the Renal Artery
Published on: April 17, 2021
[Intraoperative anaphylactic shock during renal transplantation]
Souichiro Fukushima1, Hironobu Noguchi, Kohji Teruya
1Department of Anesthesiology, Faculty of Medicine, University of the Ryukyus, Okinawa 903-0215.
Abstract:
A 32-year-old patient developed anaphylactic shock following the intravenous administration of fresh frozen plasma (FFP) during renal transplantation. The shock was reversed by intravenous adrenaline injection after stopping infusion of FFP. After the recovery from the shock state, all surgical procedures were done uneventfully and the renal function after transplantation was stable within normal ranges. Serum histamine and tryptase concentrations were significantly elevated during and immediately after the anaphylactic reaction. Although intracutaneous test could not be carried out with the FFP, we concluded that this anaphylactic shock was due to the FFP.
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