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Related Experiment Videos

Angiotensin-converting enzyme in developing lung and kidney.

K B Wallace, M D Bailie, J B Hook

    The American Journal of Physiology
    |March 1, 1978
    PubMed
    Summary

    Angiotensin-converting enzyme (ACE) activity increases after birth in rats and mice, suggesting developmental regulation. This rise in ACE may limit angiotensin II production in newborns.

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    Area of Science:

    • Biochemistry
    • Developmental Biology
    • Physiology

    Background:

    • Angiotensin-converting enzyme (ACE) converts angiotensin II (AII), a key component of the renin-angiotensin system.
    • Age-related variations in the renin-angiotensin system suggest developmental differences in ACE activity.

    Purpose of the Study:

    • To investigate the developmental changes in angiotensin-converting enzyme (ACE) activity in rats and mice.
    • To understand the role of ACE during postnatal development.

    Main Methods:

    • ACE activity was measured by quantifying hippuric acid released from hippuryl-L-histidyl-L-leucine (HHL).
    • Enzyme activity was assessed in tissue homogenates (20,000 X g supernatant) from fetal and postnatal rats and mice.
    • Substrate affinity was analyzed to determine the basis of activity changes.

    Main Results:

    • Pulmonary ACE activity in near-term fetal rats was comparable to 1-day-old neonates.
    • ACE activity demonstrated a biphasic increase during the first 6 weeks postpartum in rats.
    • Similar age-dependent increases in ACE activity were observed in rat and mouse kidneys and mouse lungs.
    • The observed increase in ACE activity was attributed to elevated enzyme content, as substrate affinity remained constant.

    Conclusions:

    • ACE activity is developmentally regulated, increasing significantly after birth in rodents.
    • The low ACE activity in newborns may serve to restrict angiotensin II production.
    • Understanding ACE developmental patterns is crucial for the renin-angiotensin system's role throughout life.

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