Pentagastrin and histamine in the regulation of gastric mucosal blood flow

The current state of our knowledge concerning mediator(s) of the increase in gastric mucosal blood flow that occurs during pentagastrin- and histamine-stimulated acid secretion is reviewed. Evidence for a role for adenosine, prostaglandin, and histamine is presented and discussed. The dose relationship between the acid-stimulatory and the vascular permeability effects of histamine is also presented.