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Updated: Jun 13, 2026
08:45
Tissue Engineering of the Intestine in a Murine Model
Published on: December 1, 2012
Intestine transplantation in the United States, 1999-2008
G V Mazariegos1, D E Steffick, S Horslen
1Children's Hospital of Pittsburgh of UPMC Hillman Center for Pediatric Transplantation, Pittsburgh, PA, USA. george.mazariegos@chp.edu
Summary
Intestine transplantation survival rates have improved, but mortality remains high, especially for infants and those with liver failure. Enhancing organ recovery and donor consent are crucial for increasing access to this life-saving procedure.
Area of Science:
- Transplantation immunology
- Gastroenterology
- Organ recovery and utilization
Background:
- Short-term outcomes in intestine transplantation have improved, with nearly 700 patients alive with functioning allografts by 2007.
- Despite improvements in transplant time and reduced waiting list mortality, overall mortality remains a significant concern, particularly for pediatric and adult patients with concurrent liver failure.
Purpose of the Study:
- To assess the current status and challenges of intestine transplantation in the United States.
- To identify opportunities for improving organ recovery and utilization rates.
- To evaluate patient and graft survival, immunosuppression practices, and long-term outcomes.
Main Methods:
- Analysis of patient and graft survival data for intestine-only and liver-intestine recipients.
- Review of immunosuppression strategies, including induction therapy.
- Examination of organ donor consent practices and recovery rates.
Main Results:
- One-year patient and graft survival rates are 89% and 79% for intestine-only, and 72% and 69% for liver-intestine recipients.
- Ten-year survival rates decrease significantly to 46% and 29% (intestine-only) and 42% and 39% (liver-intestine).
- Acute rejection occurs in 30%-40% of recipients within the first year; long-term outcomes and chronic rejection remain areas for investigation.
Conclusions:
- Intestine transplantation offers improved short-term survival, but long-term graft and patient survival require further enhancement.
- Increasing intestine donor recovery rates through improved consent and standardized criteria is essential.
- Further research is needed on long-term nutritional status, morbidities, and management of chronic rejection.
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