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Updated: Jun 13, 2026

Large Scale Non-targeted Metabolomic Profiling of Serum by Ultra Performance Liquid Chromatography-Mass Spectrometry (UPLC-MS)
07:34

Large Scale Non-targeted Metabolomic Profiling of Serum by Ultra Performance Liquid Chromatography-Mass Spectrometry (UPLC-MS)

Published on: March 14, 2013

Relative bioavailability study with two oral formulations of topiramate using a validated UPLC-MS/MS method.

I Saavedra1, E Tamayo, A Gamboa

  • 1Laboratory of Pharmacokinetics and Bioavailability, IFT, Molecular and Clinical Pharmacology Program, Biomedical Sciences Institute, Faculty of Medicine, University of Chile, Santiago, Chile.

International Journal of Clinical Pharmacology and Therapeutics
|April 28, 2010
PubMed
Summary

This study found that Toprel 100 mg is bioequivalent to Topamax 100 mg, meaning the generic anticonvulsant drug is interchangeable with the reference medication. This ensures consistent seizure control for patients.

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