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Catheter Ablation in Combination With Left Atrial Appendage Closure for Atrial Fibrillation
28:13

Catheter Ablation in Combination With Left Atrial Appendage Closure for Atrial Fibrillation

Published on: February 26, 2013

Serological predictors for the recurrence of atrial fibrillation after electrical cardioversion

Sook Kyoung Kim1, Hui-Nam Pak, Jae Hyung Park

  • 1Yonsei University Health System, Seoul, Korea.

Korean Circulation Journal
|April 28, 2010
PubMed

Insights

Electrical cardioversion (CV) for atrial fibrillation (AF) may fail in patients with high transforming growth factor beta (TGF)-beta. Recurrence of AF after successful CV is linked to older age and low stromal cell derived factor (SDF)-1alpha levels.

Area of Science:

  • Cardiology
  • Biochemistry

Background:

  • Atrial fibrillation (AF) recurrence is common after electrical cardioversion (CV).
  • Predictors for failed CV and post-successful CV recurrence remain unclear.

Purpose of the Study:

  • To identify predictors of failed electrical cardioversion (CV).
  • To investigate factors associated with atrial fibrillation (AF) recurrence after successful CV.

Main Methods:

  • 81 patients with AF undergoing CV were evaluated.
  • Clinical data and pre-CV serologic markers, including transforming growth factor beta (TGF)-beta and stromal cell derived factor (SDF)-1alpha, were assessed.
  • Follow-up was conducted for an average of 13.1 months.

Main Results:

  • 8.6% of patients experienced failed CV.
  • 32.1% had late recurrence of AF (LRAF), and 27.16% had early recurrence (ERAF).
  • High TGF-beta levels predicted failed CV (p=0.0260). Older age (p=0.0220) and lower SDF-1alpha levels (p=0.0105) were associated with AF recurrence.

Conclusions:

  • High TGF-beta levels are a predictor of failed electrical cardioversion.
  • Older age and low SDF-1alpha levels are associated with post-CV atrial fibrillation recurrence.
Abstract

Keywords:
Atrial fibrillationElectric countershockRecurrence

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