Prion proteins and copper ions. Biological and chemical controversies
Henryk Kozlowski1, Marek Luczkowski, Maurizio Remelli
1Faculty of Chemistry, University of Wroclaw, F. Joliot-Curie 14, 50-383, Wroclaw, Poland.
Dalton Transactions (Cambridge, England : 2003)
|April 28, 2010
Abstract:
The Prion protein (PrP(c)) involvement in some neurodegenerative diseases is well assessed although its "normal" biological role is not completely understood. It is known that PrP(C) can bind Cu(II) ions with high specificity but the order of magnitude of the corresponding affinity constant(s) is still highly debated. This perspective is an attempt to collect the current knowledge on these topics and to build up a bridge between the biological and the chemical points of view.
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