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Updated: Jun 13, 2026
Y-90 Radioembolization and PD-1 Inhibitor as Neoadjuvant Treatment in Hepatocellular Carcinoma
Published on: May 24, 2024
Feasibility of 90Y TOF PET-based dosimetry in liver metastasis therapy using SIR-Spheres
Renaud Lhommel1, Larry van Elmbt, Pierre Goffette
1Department of Nuclear Medicine, Cliniques Universitaires Saint Luc, Université Catholique de Louvain, Brussels, Belgium.
Purpose:
(90)Y-labelled compounds used in targeted radiotherapy are usually imaged with SPECT by recording the bremsstrahlung X-rays of the beta decay. The continuous shape of the X-ray spectrum induces the presence of a significant fraction of scatter rays in the acquisition energy window, reducing the accuracy of biodistribution and of dosimetry assessments.
Methods:
The aim of this paper is to use instead the low branch of e(-) e(+) pair production in the (90)Y decay. After administration of (90)Y-labelled SIR-Spheres by catheterization of both liver lobes, the activity distribution is obtained by (90)Y time-of-flight (TOF) PET imaging. The activity distribution is convolved with a dose irradiation kernel in order to derive the regional dosimetry distribution.
Results:
Evaluation on an anatomical phantom showed that the method provided an accurate dosimetry assessment. Preliminary results on a patient demonstrated a high-resolution absorbed dose distribution with a clear correlation with tumour response.
Conclusion:
This supports the implementation of (90)Y PET in selective internal radiation therapy of the liver.
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