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Serum resistin concentrations in children with Kawasaki disease
Hiroki Nozue1, Hironori Imai, Hisako Saitoh
1Department of Pediatrics, Tsukuba Medical Center Hospital, Tsukuba, Ibaraki, Japan. nozueh@xd5.so-net.ne.jp
Insights
Resistin levels are elevated in children with Kawasaki disease (KD) during the acute phase. While resistin is an acute inflammatory protein, it does not predict KD prognosis.
Area of Science:
- Biochemistry
- Immunology
- Pediatrics
Background:
- Resistin, primarily expressed in monocytes/macrophages, plays a role in inflammation.
- Kawasaki disease (KD) is an acute inflammatory condition in children.
Purpose of the Study:
- To investigate if resistin levels are elevated in acute Kawasaki disease.
- To determine if resistin levels correlate with KD severity.
Main Methods:
- Serum resistin concentrations were measured in 44 children with KD and 17 healthy controls.
- KD patients received aspirin and intravenous immunoglobulin (IVIG).
Main Results:
- Baseline serum resistin levels were significantly higher in KD children compared to controls.
- Resistin levels decreased to normal after IVIG therapy.
- No significant difference in baseline resistin was found between high-risk and low-risk groups for coronary artery aneurysms.
Conclusions:
- Resistin is confirmed as an acute inflammatory protein in Kawasaki disease.
- Resistin concentrations are unlikely to predict disease prognosis in acute KD.
Objective:
Human resistin is expressed strongly in monocytes or macrophages rather than in adipocytes and may play a pivotal role in inflammation. We hypothesize that resistin levels are elevated in patients with Kawasaki disease (KD) in the acute phase and may be associated with the disease severity.
Design And Subjects:
Serum resistin concentrations were measured in 44 Japanese children with KD and 17 age-matched healthy children. All the KD patients were given both aspirin and a single dose of intravenous immunoglobulin (IVIG).
Results:
The serum resistin levels at baseline in KD children were significantly higher than those in controls [33.0 (21.6-45.3) vs. 14.8 (12.4-18.6) ng/mL, P < 0.001]. After IVIG therapy, serum resistin levels were significantly decreased to normal control levels. No significant difference in baseline resistin levels was found between the high-risk group and the low-risk group of coronary artery aneurysms.
Conclusions:
We confirmed that resistin was an acute inflammatory protein, but its concentrations were unlikely to predict the prognosis of disease in acute KD patients.
