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Updated: Jun 13, 2026
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Cheek Injection Model for Simultaneous Measurement of Pain and Itch-related Behaviors
Published on: September 27, 2019
A patient with persistent pruritus
Lawrence U Liu1, Lihui Qin, A S Knisely
1Division of Liver Diseases, The Mount Sinai Medical Center, New York, New York 10029, USA. Lawrence.Liu@mountsinai.org
Seminars in Liver Disease
|April 28, 2010
Summary
This case study highlights benign recurrent intrahepatic cholestasis (BRIC), a rare liver condition presenting with jaundice and itching. Prompt diagnosis through exclusion led to successful treatment and symptom resolution.
Area of Science:
- Hepatology
- Gastroenterology
- Internal Medicine
Background:
- Benign recurrent intrahepatic cholestasis (BRIC) is a rare genetic disorder characterized by recurrent episodes of cholestasis.
- Accurate diagnosis is crucial for appropriate management and to differentiate it from other liver diseases.
Observation:
- A patient presented with acute jaundice and severe, persistent pruritus.
- Extensive laboratory and radiological investigations ruled out common causes of cholestasis, including viral hepatitis, autoimmune liver diseases, and biliary obstruction.
Findings:
- Liver biopsy revealed prominent centrilobular cholestasis.
- The diagnosis of benign recurrent intrahepatic cholestasis (BRIC) was established by excluding other potential etiologies and reviewing the clinical history.
Implications:
- This case underscores the importance of considering BRIC in patients with unexplained cholestasis.
- Timely diagnosis and management of BRIC can lead to complete clinical resolution and prevent long-term liver damage.
