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Slow-release nanoparticle-encapsulated delivery system for laryngeal injection
Vasantha L Kolachala1, Oswaldo A Henriquez, Samantha Shams
1Emory Voice Center, Department of Otolaryngology-Head and Neck Surgery, Emory University School of Medicine, Atlanta, Georgia, USA.
The Laryngoscope
|April 28, 2010
Summary
Poly(lactide-co-glycolide) (PLGA) nanoparticles provide a slow-release system for laryngeal drug delivery. This study shows sustained therapeutic agent presence in vivo, improving local treatment options.
Area of Science:
- Biomedical Engineering
- Drug Delivery Systems
- Nanotechnology
Background:
- Laryngeal therapeutics face rapid clearance, necessitating frequent injections.
- Poly(lactide-co-glycolide) (PLGA) nanoparticles offer a potential solution for sustained local drug delivery.
- Developing effective slow-release systems for the larynx is crucial for improved treatment outcomes.
Purpose of the Study:
- To evaluate the potential of poly(lactide-co-glycolide) (PLGA) nanoparticles for slow-release drug delivery to the larynx.
- To assess the in vitro and in vivo release kinetics of encapsulated therapeutics.
- To determine the functional retention of encapsulated hepatocyte growth factor (NPHGF).
Main Methods:
- Fabrication of PLGA nanoparticles loaded with Texas Red-dextran (NPTR), hepatocyte growth factor (NPHGF), and bovine serum albumin (NPBSA) using a double emulsion method.
- In vitro release studies of NPTR, NPBSA, and NPHGF over 14 days.
- In vivo assessment of NPTR release in a murine vocal fold injection model.
- In vitro evaluation of NPHGF's effect on procollagen synthesis.
Main Results:
- PLGA nanoparticles demonstrated sustained in vitro release of NPTR, NPBSA, and NPHGF over 12-14 days.
- In vivo studies showed NPTR presence for up to 7 days, significantly longer than the control.
- Encapsulated NPHGF retained its biological activity, reducing transforming growth factor-beta induced procollagen in vitro.
Conclusions:
- Poly(lactide-co-glycolide) (PLGA) nanoparticle encapsulation is a promising strategy for long-term therapeutic delivery to the larynx.
- This technology offers a potential improvement over conventional laryngeal injection methods.
- Nanoparticle-based systems can effectively deliver drugs and biologically active substances for laryngeal applications.
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