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Updated: Jun 13, 2026

Y-90 Radioembolization and PD-1 Inhibitor as Neoadjuvant Treatment in Hepatocellular Carcinoma
Published on: May 24, 2024
Can hepatocellular carcinoma be treated by Yondelis through targeting both tumor cells and tumor-associated
Chuan-Hai Zhang1, Ge-Liang Xu, Wei-Dong Jia
1Centre for the Study of Liver Cancer and Department of Hepatic Surgery, Anhui Provincial Hospital, Anhui Medical University, No. 17, Lu-Jiang Road, Hefei, Anhui, People's Republic of China. doctorzch2008@163.com
Background/Aims:
The initiation, progression, invasion and metastasis of hepatocellular carcinoma are closely associated with chronic inflammation caused by hepatitis virus infection, while tumor-associated macrophages are a major component of inflammatory infiltrates in intratumoral or peritumoral tissue of hepatocellular carcinoma.
Methodology:
Search MEDLINE, PUBMED databases, identify related articles and analyze related data.
Results:
Evidence indicated that tumor-associated macrophages play an important role in disease progression, recurrence and survival of hepatocellular carcinoma patients. However, recent study showed that Yondelis (ecteinascidin-743) can suppress tumor growth through attacking tumor cells, macrophages and tumor-associated macrophages.
Conclusions:
Owing to the importance of tumor cells and tumor-associated macrophages in inflammatory microenvironment of hepatocellular carcinoma, treating hepatocellular carcinoma by Yondelis seems to be a promising therapeutic strategy but requires further study.
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