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[Clinicopathological significance of CD137L expression in laryngeal carcinoma]
Xiaoming Li1, Xiuying Lu, Yinghui Chen
1Department of Otolaryngology-Head and Neck Surgery, Bethune International Peace Hospital, Shijiazhuang, 050082, China. xml_968@sohu.com
Objective:
To study the expression of CD137L in laryngeal carcinoma, and to analyze its clinicopathological significance.
Method:
The expression of CD137L in 50 laryngeal carcinoma specimens and 9 normal laryngeal mucous tissues were detected by immunohistochemical staining.
Result:
The positive CD137L staining were found in all 50 cases of laryngeal carcinomas (100%), while its staining were negative in normal laryngeal mucous. There was significant difference between two groups (P < 0.01). The positive ratio of CD137L staining had no relationship with the factors such as age, sex and tumor site, while it had significant correlation with the pathological stage, T stage and lymph node metastasis.
Conclusion:
The expression of CD137L might play an important role in the development of laryngeal carcinomas.
