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Updated: Jun 13, 2026
Preparation and Characterization of SDF-1α-Chitosan-Dextran Sulfate Nanoparticles
Published on: January 22, 2015
[Preparation of water-soluble chitosan solid dispersion of daidzein]
Yuebin Ge1, Xubin Wang, Weilin Guo
1School of Pharmacy, South-central University For Nationalities, Wuhan 430074, China. geyuebin@mail.scuec.edu.cn
Objective:
To enhance the dissolution rate of daidzein with solid dispersion technique.
Method:
Solid dispersions were prepared by the solvent method using water-solubility chitosan as a hydrophilic carrier. DSC, IR and X-ray methods were used to verify the formation of solid dispersion.
Result:
Dissolution percentages of solid dispersions were more than 90 percent in the drug-carrier ratio of 1:5 and 1:9. But dissolution percentages of physical mixtures and pure drug were 40 and 38.4 percent respectively. Part of daidzein dispersed in solid dispersion in the form of microcrystalline.
Conclusion:
Water-soluble chitosan solid dispersion can significantly increase dissolution rate of daidzein.
