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[Study of components in xingnaojing affecting intestine absorption of gardenia extract]
Shouying Du1, Qianyi Zhang, Yang Lu
1School of Chinese Pharmacy, Beijing University of Traditional Chinese Medicine, Beijing 100102, China. dushouying@263.net
Objective:
To observe the influence of ingredients in Xingnaojing,such as moschus, borneol and radix curcumae on intestine absorption kinetics of gardenia extract.
Method:
An in situ intestinal perfusion model of rats was employed to investigate the absorption of geniposide in gardenia extract.
Result:
While gardenia extract was administered solely, the absorptive rate constant (K) of geniposide was (0.055 +/- 0.006) h(-1); But while the extract was co-administered with radix curcumae,moschus and borneol, the K were (0.060 +/- 0.001), (0.066 +/- 0.008), (0.072 +/- 0.010) h(-1), respectively. The K was (0.076 +/- 0.011) h(-1) while the extract in total formulation for Xingnaojing.
Conclusion:
The K, while the extract is co-administered with borneol or total formulation is significantly higher than solely used. Borneol and complex prescription can significantly increase the intestinal absorption of geniposide in gardenia extract.
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