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Published on: April 19, 2024
A randomized clinical trial of two emergency contraceptive pill regimens in a Ugandan population
Josaphat K Byamugisha1, Florence M Mirembe, Elisabeth Faxelid
1Department of Obstetrics and Gynecology, Makerere University, Faculty of Medicine, Kampala, Uganda. byamugisha2001@yahoo.com
Background:
Recent trials on emergency contraception (EC) have indicated that levonorgestrel (LNG) used alone has fewer side-effects and is more efficacious than the Yuzpe regimen (high dose combined oral contraceptive pills). However, the experienced side-effects and acceptability may vary between different groups or societies.
Objective:
The primary objective of this study was to determine side-effects and acceptability of two emergency contraceptive pill (ECP) regimens among users in Kampala, Uganda.
Study Design:
Randomized clinical trial.
Methods:
A total of 337 women were enrolled in a double blind randomized clinical trial. Women requesting ECPs within 72 hours after unprotected sexual intercourse received either LNG or the Yuzpe regimen. The women returned for follow-up after three days and a follow-up interview was performed after one year.
Results:
Levonorgestrel had significantly fewer side-effects than the Yuzpe regimen (p < 0.001). There was a significant association between having worries about the method and experiencing side-effects (p < 0.001). Most women (81%) were prime users of EC. The majority would recommend ECP to other clients.
Conclusions:
Levonorgestrel is a superior option to the Yuzpe regimen and should be promoted as the recommended ECP. Having worries about ECP may influence experience of the side-effects. Correct information is critical in promotion of ECP use.
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