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Background and Environment Affect Phenotype

Background and Environment Affect Phenotype

Although the genetic makeup of an organism plays a major role in determining the phenotype, there are also several environmental factors, such as temperature, oxygen availability, presence of mutagens, that can alter an organism’s phenotype.
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Related Experiment Video

Updated: Jun 13, 2026

In Vivo Functional Study of Disease-associated Rare Human Variants Using Drosophila

In Vivo Functional Study of Disease-associated Rare Human Variants Using Drosophila

Published on: August 20, 2019

Phenotypic connections in surprising places.

Bolan Linghu¹, Charles DeLisi

¹Translational Sciences Department, Novartis Institutes for BioMedical Research, Cambridge, MA 02139, USA.

|April 29, 2010

Summary

New research reveals surprising connections between human and animal disease phenotypes. These cross-species links offer potential for novel disease models and a deeper understanding of human health.

Area of Science:

Comparative biology
Genomics
Disease modeling

Background:

Emerging evidence highlights complex correlations between human disease phenotypes.
Understanding these connections is crucial for advancing medical research.

Purpose of the Study:

To investigate and reveal cross-species phenotype connections.
To explore the potential of these connections for developing new disease models.

Main Methods:

Analysis of large-scale phenotype datasets.
Comparative genomics and bioinformatics approaches.

Main Results:

Identification of significant, previously unrecognized phenotype correlations between different species.
Demonstration of conserved biological pathways underlying related phenotypes across species.

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Why Quantification Matters: Characterization of Phenotypes at the Drosophila Larval Neuromuscular Junction

Why Quantification Matters: Characterization of Phenotypes at the Drosophila Larval Neuromuscular Junction

Published on: May 12, 2016

Related Experiment Videos

Last Updated: Jun 13, 2026

In Vivo Functional Study of Disease-associated Rare Human Variants Using Drosophila

In Vivo Functional Study of Disease-associated Rare Human Variants Using Drosophila

Published on: August 20, 2019

Navigating MARRVEL, a Web-Based Tool that Integrates Human Genomics and Model Organism Genetics Information

Navigating MARRVEL, a Web-Based Tool that Integrates Human Genomics and Model Organism Genetics Information

Published on: August 15, 2019

Why Quantification Matters: Characterization of Phenotypes at the Drosophila Larval Neuromuscular Junction

Why Quantification Matters: Characterization of Phenotypes at the Drosophila Larval Neuromuscular Junction

Published on: May 12, 2016

Conclusions:

Cross-species phenotype analysis is a powerful approach for understanding disease.
These findings open new avenues for translational research and the development of innovative disease models.