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Updated: Jun 13, 2026

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[Expression of the proteins associated with transforming growth factor-beta/Smad signaling pathway in Peutz-Jeghers
Yu-jing Wang1, Lian-jie Li, Bao-ping Wu
1Guangdong Provincial Key Laboratory of Gastroenterology/Department of Gastroenterology, Nanfang Hospital, Southern Medical University, Guangzhou 510515, China. wyjsunshine@163.com
Objective:
To detect the expression of important proteins associated with transforming growth factor-beta (TGF-beta)/Smad signaling pathway in Peutz-Jeghers syndrome (PJS) and investigate the correlation of these proteins to LKB1 gene expression.
Methods:
The expression and localization of LKB1, TGFbeta1 and pSmad2 proteins in 20 PJS polyp samples and normal intestinal mucosal tissues were detected with immunohistochemical staining.
Results:
The expressions of LKB1, TGFbeta1 and pSmad2 were lower in PJS polyps than in normal mucosa, and the differences in LKB1 and TGFbeta1 proteins were significantly different between them (P<0.05). In PJS polyps, positive correlations were found between LKB1 and TGFbeta1 and between TGFbeta1 and pSmad2 expressions.
Conclusion:
TGFbeta/Smad pathway is probably subjected to the regulation by LKB1 and may play a role in the occurrence of PJS.
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