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Updated: Jun 13, 2026
Coronary Progenitor Cells and Soluble Biomarkers in Cardiovascular Prognosis after Coronary Angioplasty
Published on: January 28, 2020
[Correlation of adiponectin, monocyte chemoattractant protein-1, and endothelial function to vascular remodeling in
Zhi-bing Wang1, Jun Liu, Shao-yuan Chen
1Department of Cardiology, Nanshan People's Hospital of Shenzhen, Shenzhen 518052, China. wang264486@hotmail.com
Objective:
To investigate the correlation between vascular remodeling index (RI) and serum adiponectin, plasma monocyte chemoattractant protein-1 (MCP-1), endothelial function and evaluate the mechanism of coronary in-stent restenosis.
Methods:
RI 6 months after percutaneous coronary intervention (PCI), serum adiponectin, plasma MCP-1 and flow-mediated dilation (FMD) before and 3 days,6 months after PCI were measured in 30 patients with and 30 without coronary in-stent restenosis.
Results:
Compared with patients without restenosis and those with restenosis before PCI, the patients with coronary in-stent restenosis showed significantly increased plasma MCP-1 3 days and 6 months after PCI (P<0.05) and reduced RI 6 months after PCI, serum adiponectin and FMD 3 days and 6 months after PCI (P<0.05). RI was positively correlated to serum adiponectin and FMD and inversely to MCP-1.
Conclusion:
The occurrence of coronary in-stent restenosis is the result of the interrelations between multiple factors.
