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Related Experiment Video

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Intrafemoral Injection of Human Hematopoietic Stem and Progenitor Cells into Immunocompromised Mice

Intrafemoral Injection of Human Hematopoietic Stem and Progenitor Cells into Immunocompromised Mice

Published on: December 8, 2023

Hematopoietic stem cell transplantation: a global perspective.

Alois Gratwohl¹, Helen Baldomero, Mahmoud Aljurf

¹European Group for Blood andMarrow Transplantation, Transplant Activity Survey Office, Department of Hematology, University Hospital Basel, Basel, Switzerland. hematology@uhbs.ch

|April 29, 2010

Summary

Hematopoietic stem cell transplantation (HSCT) is globally utilized for various conditions. Higher income countries, greater healthcare spending, and more transplant teams correlate with increased HSCT rates.

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Area of Science:

Hematology
Transplant Medicine
Global Health

Background:

Hematopoietic stem cell transplantation (HSCT) is a complex procedure requiring substantial resources.
Global data on HSCT utilization and influencing factors remain limited.

Purpose of the Study:

To analyze the worldwide use of HSCT.
To identify disparities in HSCT application across different regions.
To explore the relationship between macroeconomic indicators and HSCT rates globally.

Main Methods:

A retrospective survey of 1327 centers across 71 countries in 2006.
Data collected on allogeneic and autologous HSCT procedures.
Analysis of transplant rates, indications, donor types, and macroeconomic factors.

Main Results:

Over 50,000 first HSCTs were performed, with 57% autologous and 43% allogeneic.
HSCT rates varied significantly by region, with Europe showing the highest median rates.
HSCT was not performed in countries with populations under 300,000, small land areas, or low gross national income per capita (<$680).
Government health expenditure, HSCT team density, human development index, and gross national income per capita were strongly associated with HSCT rates.

Conclusions:

Hematopoietic stem cell transplantation is applied to a wide range of diseases globally.
Higher-income nations with robust healthcare systems and established transplant infrastructure utilize HSCT more frequently.