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Updated: Jun 13, 2026

Fertility Preservation in Patients with Severe Ovarian Dysfunction
Published on: March 25, 2021
Treatment of premature ovarian failure trial: description of an ongoing clinical trial
Beth Cartwright1, Jillian Robinson, Janice Rymer
1Menopause Research Unit, McNair Centre, Ground Floor Southwark Wing, Guy's Hospital, London SE1 9RT, UK. beth.cartwright@kcl.ac.uk
Abstract:
Premature ovarian failure is a relatively common clinical condition, and carries important long-term health consequences. Estrogen replacement is recommended to alleviate unpleasant hypo-estrogenic symptoms and reduce long-term health risks. However, the most suitable form of estrogen replacement, and the exact effects of no treatment, is unknown. Surprisingly, little research has been carried out in this area. We describe the design of an ongoing clinical trial that will address these issues so that we can begin to provide evidence-based care for affected women.
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