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Updated: Jun 13, 2026

Non-invasive Assessment of Microvascular and Endothelial Function
Published on: January 29, 2013
Synchronized changes in serum vascular endothelial growth factor during the clinical course of chronic systemic
Yoshiaki Kinoshita1, Shunji Kasaoka, Motoki Fujita
1Advanced Medical Emergency and Critical Care Center, Yamaguchi University Hospital, Ube. yoshi-kino@umin.ac.jp
Abstract:
Systemic capillary leak syndrome (SCLS) is a rare disease characterized by leakage of plasma from blood vessels into the interstitial space due to increased capillary permeability. We describe a 24-year-old man who was hospitalized with systemic edema, hypoalbuminemia, and disseminated intravascular coagulation. After extensive investigative procedures, he was diagnosed with chronic SCLS and made a gradual recovery after starting on prednisolone, terbutaline, and theophylline. We measured the patient's serum vascular endothelial growth factor (VEGF) over time and found a relationship between serum VEGF and the clinical course.
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