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Updated: Jun 13, 2026
06:09
Spatial and Temporal Control of Murine Melanoma Initiation from Mutant Melanocyte Stem Cells
Published on: June 7, 2019
Trauma as triggering factor for development of melanocytic nevi
Alexander A Navarini1, Isabel Kolm, Ximena Calvo
1Department of Dermatology, University Hospital of Zurich, Gloriastrasse 31, Zurich, Switzerland. alexander.navarini@usz.ch
Dermatology (Basel, Switzerland)
|April 29, 2010
Summary
Minor skin trauma can trigger eruptive nevi in predisposed individuals. This case study highlights how localized injury can lead to the development of multiple acquired melanocytic nevi, suggesting trauma as a key factor.
Area of Science:
- Dermatology
- Pathology
Background:
- The origins of acquired melanocytic nevi are not fully understood.
- Factors influencing nevus development include age, genetics, and environmental triggers like UV exposure and immunosuppression.
Observation:
- A 66-year-old woman developed eruptive nevi in a linear pattern on her calf following minor skin erosion from ski boot friction.
- Dermatopathology revealed multiple junctional melanocytic proliferations with cellular atypia.
Findings:
- Localized superficial trauma can act as a trigger for eruptive nevi.
- Growth factors released by damaged keratinocytes and inflammatory cells may induce nevus cell proliferation.
- Immunosuppression might reduce surveillance, allowing existing nevus cells to proliferate.
Implications:
- Minor trauma can be a significant trigger for acquired melanocytic nevi in susceptible individuals.
- Understanding these triggers may inform future research into nevus development and management.
- This case underscores the link between external stimuli and melanocytic proliferation.
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