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Vitamin D, surface electromyography and physical function in uraemic patients
J G Heaf1, S Molsted, A P Harrison
1Department of Nephrology, Copenhagen University Hospital in Herlev, Herlev, Denmark. heaf @ dadlnet.dk
Nephron. Clinical Practice
|April 29, 2010
Summary
Vitamin D deficiency is common in patients with chronic kidney disease (CKD) and on peritoneal dialysis (PD). Muscle and physical function were not directly associated with 25-hydroxyvitamin D levels in this study.
Area of Science:
- Nephrology
- Endocrinology
- Musculoskeletal Health
Background:
- Muscle dysfunction is a known complication in uraemic patients.
- 25-hydroxyvitamin D (25-OHD) deficiency is a potential contributor to myopathy in these patients.
Purpose of the Study:
- To investigate the association between 25-hydroxyvitamin D (25-OHD) levels and muscle/physical function in chronic kidney disease (CKD) and peritoneal dialysis (PD) patients.
Main Methods:
- Cross-sectional study of 21 CKD (stage 3-5) and 21 PD patients.
- Assessed 25-OHD, 1,25-dihydroxycholecalciferol, and parathyroid hormone.
- Measured muscle function via surface electromyography (sEMG) and physical function using the 30-second Chair Stand Test and SF-36 questionnaire.
Main Results:
- High prevalence of 25-OHD deficiency (52% in CKD, 71% in PD).
- No significant correlation found between 25-OHD levels and sEMG or physical function tests.
- Higher sEMG frequency and RMS correlated positively with Chair Stand Test scores and quality of life metrics.
Conclusions:
- 25-OHD deficiency is prevalent in uraemic patients.
- Muscle and physical function were not directly associated with 25-OHD levels in this cohort.
- Limited variation in 25-OHD and confounding factors in this patient population may influence results.
