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Updated: Jun 13, 2026
11:25
Targeting Cysteine Thiols for in Vitro Site-specific Glycosylation of Recombinant Proteins
Published on: October 4, 2017
Site-specific functionalisation of proteins by a Staudinger-type reaction using unsymmetrical phosphites
Verena Böhrsch1, Remigiusz Serwa, Paul Majkut
1Institut für Chemie und Biochemie, Freie Universität Berlin, Takustr. 3, 14195 Berlin, Germany.
Chemical Communications (Cambridge, England)
|April 29, 2010
Abstract:
Unsymmetrical phosphites react efficiently in a Staudinger reaction with p-azido-phenylalanine, which can be applied for the biotinylation of proteins, thereby expanding the scope of the chemoselective Staudinger-phosphite reaction of aryl azides with symmetrical phosphites to the corresponding phosphoramidates.
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