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Development of Recombinant Proteins to Treat Chronic Pain
10:37

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Published on: April 11, 2018

Immunoglobulin responsive chronic pain.

Andreas Goebel1

  • 1Pain Research Institute, 3rd Floor, Clinical Sciences Centre, Liverpool University, Liverpool, UK. andreasgoebel@rocketmail.com

Journal of Clinical Immunology
|April 29, 2010
PubMed
Summary
This summary is machine-generated.

Intravenous immunoglobulin (IVIG) shows promise for treating chronic pain conditions like complex regional pain syndrome. Further research is needed to determine optimal IVIG dosing and its effects on patient function and quality of life.

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Area of Science:

  • Neuroimmunology
  • Pain Medicine
  • Pharmacology

Background:

  • Glial-mediated neuroimmune activation is implicated in chronic pain.
  • Immune modulation presents a potential therapeutic avenue for pain management.

Purpose of the Study:

  • To review the evidence for intravenous immunoglobulin (IVIG) in treating chronic pain conditions.
  • To assess the efficacy and identify knowledge gaps regarding IVIG therapy for pain.

Main Methods:

  • Systematic search of Medline and international trial registries.
  • Keywords included "intravenous immunoglobulin" or "IVIG," and various pain conditions.

Main Results:

  • Randomized controlled trials (RCTs) indicate IVIG is effective for complex regional pain syndrome (low-dose) and post-polio syndrome (high-dose).
  • Open trials suggest IVIG efficacy in other pain conditions.

Conclusions:

  • IVIG therapy may be a novel treatment for refractory chronic pain.
  • Further studies are required to establish optimal IVIG doses, treatment duration, and impact on function and quality of life.