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Related Concept Videos

Brain Imaging01:14

Brain Imaging

Brain imaging technologies provide critical insights into both the structure and function of the human brain, enabling medical professionals and researchers to diagnose, study, and treat neurological disorders or psychiatric disorders more effectively.
These technologies include computerized axial tomography (CAT or CT scans), positron-emission tomography (PET scans),  magnetic resonance imaging (MRI),  functional magnetic resonance imaging (fMRI), and Transcranial Magnetic Stimulation (TMS).

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Related Experiment Video

Updated: Jun 13, 2026

Translational Brain Mapping at the University of Rochester Medical Center: Preserving the Mind Through Personalized Brain Mapping
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Neurocognitive function in brain tumors.

Denise D Correa1

  • 1Department of Neurology, Memorial Sloan-Kettering Cancer Center, 1275 York Avenue, New York, NY 10021, USA. corread@mskcc.org

Current Neurology and Neuroscience Reports
|April 29, 2010
PubMed
Summary

Cognitive dysfunction is a major concern for brain tumor patients, especially long-term survivors. Radiotherapy and chemotherapy can cause significant neurotoxicity affecting memory, attention, and executive functions.

Area of Science:

  • Neuro-oncology
  • Radiation oncology
  • Clinical neurosciences

Background:

  • Cognitive dysfunction is a frequent complication in brain tumor patients, impacting long-term survivors.
  • Adverse effects from radiotherapy (RT) and chemotherapy contribute significantly to neurotoxicity.
  • Whole-brain RT, particularly with chemotherapy, exacerbates cognitive deficits more than other treatment modalities.

Purpose of the Study:

  • To review the literature on cognitive dysfunction in brain tumor patients.
  • To identify cognitive domains affected by cancer treatments.
  • To summarize current understanding of treatment-related neurotoxicity and ongoing research.

Main Methods:

  • Literature review of studies and clinical trials.
  • Analysis of cognitive outcome measures in brain tumor patients.

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  • Examination of pathophysiologic mechanisms of RT and chemotherapy-induced brain injury.

    • Main Results:

    • Cognitive domains affected include attention, executive functions, memory, and graphomotor speed.
    • Whole-brain RT with chemotherapy leads to more pronounced cognitive dysfunction.
    • Studies increasingly incorporate cognitive measures to assess neurotoxicity.

    Conclusions:

    • Treatment-induced cognitive dysfunction is a significant challenge for brain tumor patients.
    • Understanding neurotoxicity mechanisms is crucial for developing interventions.
    • Research is actively investigating preventive and therapeutic strategies for cognitive decline.