Related Experiment Video
Updated: Jun 13, 2026

A Method of Trigonometric Modelling of Seasonal Variation Demonstrated with Multiple Sclerosis Relapse Data
Published on: December 9, 2015
The SEAS Trial
1Veterans Affairs Medical Center, Houston, TX 77030, USA. blaseanthony.carabello@med.va.gov
Abstract:
The pathobiology of aortic stenosis (AS) now is recognized to have many similiarities to that of atherosclerosis, a disease in which lipid lowering therapy with statin drugs has been successful. Accordingly statins have been used to attempt to retard the progression of AS with variable success. The SEAS trial compared the effects of the combination of simvastatin and ezetimibe to placebo in retarding the progression of aortic stenosis (AS) and was the largest randomized trial of such therapies. One thousand eight hundred seventy three patients with moderate AS were included. The group receiving the drugs had a large reduction in LDL cholesterol and a reduction in coronary events. However drug therapy had no effect on the progression of AS. Conclusion. While AS has many similarities to atherosclerosis, lipid lowering therapy does not affect progression of moderate to severe AS.
Related Concept Videos
Clinical Trials
There are four phases in a clinical trial. A phase one...
Biological Clocks and Seasonal Responses
Clinical Trials: Overview
Trial and Error and Algorithm
Seasoning of Wood
Achieving equilibrium moisture content is the goal of seasoning; this is the point where the wood's moisture content stabilizes to align with the moisture levels of the surrounding environment. Proper...
Data Collection by Experiments
An example of the experimental method is a public clinical trial...

