Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

Clinical Trials01:16

Clinical Trials

Clinical trials are prospective experimental studies conducted on humans to determine the safety and efficacy of treatments, drugs, diet methods, and medical devices. Using statistics in clinical trials enables researchers to derive reasonable and accurate conclusions from the collected data, allowing them to make wise decisions in uncertain situations. In medical research, statistical methods are crucial for preventing errors and bias.
There are four phases in a clinical trial. A phase one...
Biological Clocks and Seasonal Responses02:45

Biological Clocks and Seasonal Responses

The circadian—or biological—clock is an intrinsic, timekeeping, molecular mechanism that allows plants to coordinate physiological activities over 24-hour cycles called circadian rhythms. Photoperiodism is a collective term for the biological responses of plants to variations in the relative lengths of dark and light periods. The period of light-exposure is called the photoperiod.
Clinical Trials: Overview01:11

Clinical Trials: Overview

Clinical development focuses on how the drug will interact with the human body and encompasses four key phases of clinical trials, each serving a specific purpose in assessing the safety and effectiveness of new drugs. These phases overlap and build upon one another. Phase I involves a small group of healthy volunteers (typically 20-80 individuals) or, in cases where significant toxicity is expected, patients with the targeted disease, such as cancer or AIDS. The volunteers are tested for...
Trial and Error and Algorithm01:12

Trial and Error and Algorithm

A problem-solving strategy is a plan of action used to find a solution. Different strategies have distinct action plans. Trial and error involves trying different solutions until one works. For instance, to fix a broken printer, you might check ink levels, ensure the paper tray isn't jammed, and verify the printer's connection to your laptop. This method can be time-consuming but is commonly used. Thomas Edison, for example, used trial and error to find a suitable filament for the light bulb,...
Seasoning of Wood01:15

Seasoning of Wood

Seasoning of wood is a crucial process aimed at reducing and stabilizing the moisture content within the wood to prevent future shrinkage, structural damage, or aesthetic issues once the wood is used in construction. Wood naturally swells when it absorbs moisture and contracts as it dries.
Achieving equilibrium moisture content is the goal of seasoning; this is the point where the wood's moisture content stabilizes to align with the moisture levels of the surrounding environment. Proper...
Data Collection by Experiments01:13

Data Collection by Experiments

Data collection is a systematic method of obtaining, observing, measuring, and analyzing accurate information. An experimental study is a standard method of data collection that involves the manipulation of the samples by applying some form of treatment prior to data collection. It refers to manipulating one variable to determine its changes on another variable. The sample subjected to treatment is known as “experimental units.”
An example of the experimental method is a public clinical trial...

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Exercise Mildly Increases Transaortic Gradients in Aortic Stenosis With Preserved Ejection Fraction: An Invasive Hemodynamic Study.

Catheterization and cardiovascular interventions : official journal of the Society for Cardiac Angiography & Interventions·2025
Same author

Transcatheter Closure of a Rare Right Pulmonary Artery-Left Atrial Fistula in an Adult.

Journal of the Society for Cardiovascular Angiography & Interventions·2024
Same author

Clinical Implications of Variability in Left Ventricular Ejection Fraction Determined by Echocardiography and Cardiac Magnetic Resonance.

Journal of the American Society of Echocardiography : official publication of the American Society of Echocardiography·2024
Same author

Second-generation extracellular matrix patch for epicardial infarct repair.

Journal of cardiothoracic surgery·2023
Same author

Long-Term Major Adverse Cardiovascular Events in Patients "Appropriately" Tested for Troponin Assays in Emergency Department.

Current problems in cardiology·2023
Same author

Optimal antiplatelet and antithrombotic regimen post-transcatheter aortic valve replacement.

European journal of clinical investigation·2023

Related Experiment Video

Updated: Jun 13, 2026

A Method of Trigonometric Modelling of Seasonal Variation Demonstrated with Multiple Sclerosis Relapse Data
10:46

A Method of Trigonometric Modelling of Seasonal Variation Demonstrated with Multiple Sclerosis Relapse Data

Published on: December 9, 2015

The SEAS Trial.

Blase A Carabello1

  • 1Veterans Affairs Medical Center, Houston, TX 77030, USA. blaseanthony.carabello@med.va.gov

Current Cardiology Reports
|April 29, 2010
PubMed
Summary

Lipid-lowering therapy with statins did not slow the progression of aortic stenosis (AS) in patients with moderate disease. Despite reducing LDL cholesterol and coronary events, the treatment showed no effect on AS progression.

Area of Science:

  • Cardiovascular Medicine
  • Pharmacology
  • Clinical Trials

Background:

  • Aortic stenosis (AS) shares pathobiological similarities with atherosclerosis.
  • Lipid-lowering therapy, particularly statins, has proven effective in managing atherosclerosis.
  • Previous attempts to use statins for AS have yielded variable results.

Purpose of the Study:

  • To evaluate the efficacy of lipid-lowering therapy in retarding the progression of moderate aortic stenosis.
  • To assess the impact of simvastatin and ezetimibe combination therapy versus placebo on AS progression.

Main Methods:

  • The study was a large-scale, randomized trial involving 1,873 patients with moderate AS.
  • Participants received either simvastatin plus ezetimibe or a placebo.

More Related Videos

JenaTron - An Experimental Approach to Study the Effects of Plant History and Soil History on Grassland Ecosystem Functioning
09:23

JenaTron - An Experimental Approach to Study the Effects of Plant History and Soil History on Grassland Ecosystem Functioning

Published on: March 21, 2025

The Power of Interstimulus Interval for the Assessment of Temporal Processing in Rodents
10:27

The Power of Interstimulus Interval for the Assessment of Temporal Processing in Rodents

Published on: April 19, 2019

Related Experiment Videos

Last Updated: Jun 13, 2026

A Method of Trigonometric Modelling of Seasonal Variation Demonstrated with Multiple Sclerosis Relapse Data
10:46

A Method of Trigonometric Modelling of Seasonal Variation Demonstrated with Multiple Sclerosis Relapse Data

Published on: December 9, 2015

JenaTron - An Experimental Approach to Study the Effects of Plant History and Soil History on Grassland Ecosystem Functioning
09:23

JenaTron - An Experimental Approach to Study the Effects of Plant History and Soil History on Grassland Ecosystem Functioning

Published on: March 21, 2025

The Power of Interstimulus Interval for the Assessment of Temporal Processing in Rodents
10:27

The Power of Interstimulus Interval for the Assessment of Temporal Processing in Rodents

Published on: April 19, 2019

  • Outcomes measured included the progression of AS and coronary events.

    • Main Results:

    • The active treatment group achieved significant reductions in LDL cholesterol and experienced fewer coronary events.
    • However, the combination therapy demonstrated no significant effect on the progression of aortic stenosis.
    • The study was the largest randomized trial to investigate this therapeutic approach in moderate AS.

    Conclusions:

    • Despite shared characteristics with atherosclerosis, lipid-lowering therapy does not influence the progression of moderate to severe aortic stenosis.
    • Further research may be needed to identify effective pharmacological interventions for aortic stenosis.