Search research articles

ABOUT JoVE

Overview Leadership Blog JoVE Help Center

AUTHORS

Publishing Process Editorial Board Scope & Policies Peer Review FAQ Submit

LIBRARIANS

Testimonials Subscriptions Access Resources Library Advisory Board FAQ

RESEARCH

JoVE Journal Methods Collections JoVE Encyclopedia of Experiments Archive

EDUCATION

JoVE Core JoVE Business JoVE Science Education JoVE Lab Manual Faculty Resource Center Faculty Site

Terms & Conditions of Use

Related Concept Videos

Multiple Sclerosis l: Introduction

Multiple Sclerosis l: Introduction

Multiple sclerosis is a chronic autoimmune disease of the central nervous system (CNS) that affects the brain, spinal cord, and optic nerves. It is an inflammatory demyelinating disorder and a leading cause of neurological disability in young adults.EpidemiologyMS commonly begins between 20 and 40 years of age and is twice as common in women. Its exact cause remains unclear, but genetic susceptibility contributes, with higher risk in first-degree relatives and identical twins. A greater...

Peripheral Arterial Disease II: Clinical Manifestations and Diagnostic Evaluation

Peripheral Arterial Disease II: Clinical Manifestations and Diagnostic Evaluation

Clinical manifestationsPeripheral Arterial Disease (PAD) manifests through a range of symptoms, from the characteristic intermittent claudication to atypical presentations and severe complications in advanced stages. Intermittent claudication, a hallmark symptom of PAD, presents as exercise-induced muscle pain that typically resolves within minutes of rest. This pain is reproducible and stems from inadequate blood flow, leading to the accumulation of lactic acid produced during anaerobic...

Nociception

Nociception

Nociception—the ability to feel pain—is essential for an organism’s survival and overall well-being. Noxious stimuli such as piercing pain from a sharp object, heat from an open flame, or contact with corrosive chemicals are first detected by sensory receptors, called nociceptors, located on nerve endings. Nociceptors express ion channels that convert noxious stimuli into electrical signals. When these signals reach the brain via sensory neurons, they are perceived as pain. Thus, pain helps the...

Analgesia and Pain Management

Analgesia and Pain Management

Pain is critical to various clinical pathologies, provoking an urgent need for effective management. Pain, whether acute or chronic, is a complex neurochemical process. Its alleviation depends on the type, with nonopioid analgesics effective for mild to moderate pain, such as musculoskeletal or inflammatory pain, while neuropathic pain responds best to anticonvulsants, tricyclic antidepressants, or serotonin/norepinephrine reuptake inhibitors. For severe acute or chronic pain, opioids may be...

Degenerative Disc Disease ll: Pathophysiology

Degenerative Disc Disease ll: Pathophysiology

The symptoms of degenerative disc disease arise from a combination of mechanical compression, vascular compromise, and biochemical inflammation, which together disrupt nerve function and produce pain.Mechanical CompressionDisc degeneration reduces height and elasticity, predisposing to herniation of the nucleus pulposus, a major cause of radicular pain. Herniations may be protrusion (bulging with intact annulus), extrusion (nucleus extends beyond disc but remains connected), or sequestration...

Peripheral Artery Disease V: Postoperative Nursing Management

Peripheral Artery Disease V: Postoperative Nursing Management

During the postoperative period, it is crucial to focus on maintaining circulation, identifying and managing potential complications, and planning for discharge.Nursing AssessmentVital signs monitoring: Regularly monitor vital signs, including blood pressure, heart rate, respiratory rate, and temperature, to detect early signs of complications such as bleeding and infection.Circulation assessment: Monitor pulses, perform Doppler assessments, and check capillary refill, color, temperature, and...

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by

Same author

Liquid biopsy-based diagnostic evaluation of hypermethylated CpG sites for ovarian cancer diagnosis.

Molecular oncology·2026

Same author

<i>in vitro</i> comparison of surgical guide technologies on osteotomy precision in anterior maxillary implant sites.

Bioinformation·2026

Same author

Impact of LV Dilatation on Outcomes of Concomitant Mitral Valve Repair in Patients Undergoing CABG With Moderate Ischemic MR.

The Annals of thoracic surgery·2026

Same author

Comparative evaluation of CBCT and MRI in detecting simulated TMJ disc displacement: An <i>in vitro</i> study.

Bioinformation·2026

Same author

Managing Orbital Floor Fractures With Three-Dimensional (3D)-Printed Surgical Guides: A Narrative Review.

Cureus·2026

Same author

Efficacy of Single-Dose Preoperative Dexamethasone in Managing Pain, Swelling, and Trismus After Impacted Mandibular Third Molar Surgery: A Clinical Study.

Journal of pharmacy & bioallied sciences·2026

Search research articles

Related Experiment Video

Updated: Jun 13, 2026

Targeted Muscle Reinnervation: Surgical Protocol for a Randomized Controlled Trial in Postamputation Pain

Targeted Muscle Reinnervation: Surgical Protocol for a Randomized Controlled Trial in Postamputation Pain

Published on: March 8, 2024

Multiple sclerosis-related central pain disorders.

Turo J Nurmikko¹, Sameer Gupta, Kate Maclver

¹Neuroscience Research Unit, Clinical Sciences Centre, Lower Lane, Liverpool, L9 7AL, UK. tjn@liverpool.ac.uk

Current Pain and Headache Reports

|April 29, 2010

Summary

This summary is machine-generated.

Central neuropathic pain is a common and disabling symptom in multiple sclerosis (MS). Current management strategies for MS pain are varied, with a need for more clinical trials and understanding of underlying mechanisms.

More Related Videos

Dynamic Quantitative Sensory Testing to Characterize Central Pain Processing

Dynamic Quantitative Sensory Testing to Characterize Central Pain Processing

Published on: February 16, 2017

Regenerative Peripheral Nerve Interface: Surgical Protocol for a Randomized Controlled Trial in Postamputation Pain

Regenerative Peripheral Nerve Interface: Surgical Protocol for a Randomized Controlled Trial in Postamputation Pain

Published on: March 15, 2024

Related Experiment Videos

Last Updated: Jun 13, 2026

Targeted Muscle Reinnervation: Surgical Protocol for a Randomized Controlled Trial in Postamputation Pain

Targeted Muscle Reinnervation: Surgical Protocol for a Randomized Controlled Trial in Postamputation Pain

Published on: March 8, 2024

Dynamic Quantitative Sensory Testing to Characterize Central Pain Processing

Dynamic Quantitative Sensory Testing to Characterize Central Pain Processing

Published on: February 16, 2017

Regenerative Peripheral Nerve Interface: Surgical Protocol for a Randomized Controlled Trial in Postamputation Pain

Regenerative Peripheral Nerve Interface: Surgical Protocol for a Randomized Controlled Trial in Postamputation Pain

Published on: March 15, 2024

Area of Science:

Neurology
Pain Medicine
Neuroimmunology

Background:

Central neuropathic pain is highly prevalent in multiple sclerosis (MS), escalating with physical disability.
Specific pain types like dysesthetic pain, trigeminal neuralgia, Lhermitte's sign, and painful tonic spasms are linked to MS-related plaques.
The relationship between MS and headache or back pain is not well-established.

Purpose of the Study:

To review the current understanding and management of central neuropathic pain in multiple sclerosis.
To highlight the association between specific pain types and MS pathophysiology.
To identify challenges and future directions in managing MS-related pain.

Main Methods:

Review of existing literature on central neuropathic pain in MS.
Analysis of the pathophysiological links between MS lesions and various pain syndromes.
Evaluation of current and emerging treatment modalities for different types of MS pain.

Main Results:

Dysesthetic pain in MS is typically managed with general neuropathic pain treatments, with potential benefits from cannabinoids and levetiracetam.
MS-related trigeminal neuralgia may benefit from neuroablative procedures prior to microvascular decompression due to its unique characteristics.
Headache and back pain associations in MS require further investigation.

Conclusions:

Effective management of MS-related pain is hampered by a lack of controlled clinical trials and incomplete understanding of pain mechanisms.
Tailored treatment approaches are necessary for different types of neuropathic pain experienced by MS patients.
Further research into pathophysiology and clinical trials is crucial for developing systematic pain management strategies in MS.