Search research articles

ABOUT JoVE

Overview Leadership Blog JoVE Help Center

AUTHORS

Publishing Process Editorial Board Scope & Policies Peer Review FAQ Submit

LIBRARIANS

Testimonials Subscriptions Access Resources Library Advisory Board FAQ

RESEARCH

JoVE Journal Methods Collections JoVE Encyclopedia of Experiments Archive

EDUCATION

JoVE Core JoVE Business JoVE Science Education JoVE Lab Manual Faculty Resource Center Faculty Site

Terms & Conditions of Use

Related Concept Videos

Nociception

Nociception

Nociception—the ability to feel pain—is essential for an organism’s survival and overall well-being. Noxious stimuli such as piercing pain from a sharp object, heat from an open flame, or contact with corrosive chemicals are first detected by sensory receptors, called nociceptors, located on nerve endings. Nociceptors express ion channels that convert noxious stimuli into electrical signals. When these signals reach the brain via sensory neurons, they are perceived as pain. Thus, pain helps the...

Local Anesthetics: Differential Sensitivity of Nerve Fibers

Local Anesthetics: Differential Sensitivity of Nerve Fibers

Local anesthetics (LAs) block the sodium channels of nerve trunks, sensory nerve endings, and neuromuscular junctions. Although LAs can block all kinds of nerves, the sensitivity of nerve fibers differs according to nerve types and structures. LAs are known to block myelinated fibers faster than unmyelinated ones. Also, they block pain or sensory neurons at low concentrations without affecting the motor neurons involved in muscle contractions. This helps relieve labor pain without affecting the...

Chemotherapy-Induced Nausea and Vomiting: Dopamine Receptor Antagonists

Chemotherapy-Induced Nausea and Vomiting: Dopamine Receptor Antagonists

Dopamine receptor antagonists, also known as antipsychotic agents, are critical in managing chemotherapy-induced vomiting. These antiemetic agents block dopamine receptors in the chemoreceptor trigger zone (CTZ), inhibiting signal transmission to the vomiting center. Antipsychotic agents encompass phenothiazines (PTZ), butyrophenones, benzamides, and thienobenzodiazepines (Zyprexa), which are utilized for their antiemetic and sedative properties.
Phenothiazines, such as prochlorperazine...

Analgesia and Pain Management

Analgesia and Pain Management

Pain is critical to various clinical pathologies, provoking an urgent need for effective management. Pain, whether acute or chronic, is a complex neurochemical process. Its alleviation depends on the type, with nonopioid analgesics effective for mild to moderate pain, such as musculoskeletal or inflammatory pain, while neuropathic pain responds best to anticonvulsants, tricyclic antidepressants, or serotonin/norepinephrine reuptake inhibitors. For severe acute or chronic pain, opioids may be...

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by

Same author

Epithelial cancer cells co-opt the death ligand TRAIL to avert extrinsic apoptosis while acquiring killing capacity.

Cell death and differentiation·2026

Same author

Chemically-induced degradation of the endoplasmic-reticulum stress sensor IRE1 by a VHL-recruiting chimera.

Nature communications·2025

Same author

Interferon regulatory factor 4 mediates nonenzymatic IRE1 dependency in multiple myeloma cells.

PLoS biology·2025

Same author

A nonenzymatic dependency on inositol-requiring enzyme 1 controls cancer cell cycle progression and tumor growth.

PLoS biology·2025

Same author

Homeostasis control in health and disease by the unfolded protein response.

Nature reviews. Molecular cell biology·2024

Same author

ATF6 Promotes Colorectal Cancer Growth and Stemness by Regulating the Wnt Pathway.

Cancer research communications·2024

Search research articles

Related Experiment Video

Updated: Jun 13, 2026

3D-Neuronavigation In Vivo Through a Patient's Brain During a Spontaneous Migraine Headache

3D-Neuronavigation In Vivo Through a Patient's Brain During a Spontaneous Migraine Headache

Published on: June 2, 2014

Allodynia in cluster headache.

Avi Ashkenazi¹

¹The Neurologic Group of Bucks/Montgomery County, Doylestown, PA 18901, USA. aashkenazi2001@yahoo.com

Current Pain and Headache Reports

|April 29, 2010

Summary

Cutaneous allodynia (CA), pain from non-painful stimuli, is increasingly recognized in cluster headache (CH). Further research is needed to understand its mechanisms and clinical significance in CH patients.

Area of Science:

Neurology
Pain Medicine
Headache Disorders

Background:

Cutaneous allodynia (CA) involves pain perception from non-noxious stimuli on normal skin.
CA is linked to central sensitization in brainstem and thalamic neurons in headache syndromes.
Recognition of CA in cluster headache (CH) is recent, with limited data available.

Purpose of the Study:

To review the current understanding of cutaneous allodynia (CA) in cluster headache (CH).
To highlight the characteristics and potential mechanisms of CA in CH.
To identify knowledge gaps and suggest future research directions.

Main Methods:

Literature review of studies investigating CA in cluster headache.
Analysis of clinical characteristics of CA in CH patients.

More Related Videos

Dural Stimulation and Periorbital von Frey Testing in Mice As a Preclinical Model of Headache

Dural Stimulation and Periorbital von Frey Testing in Mice As a Preclinical Model of Headache

Published on: July 29, 2021

Related Experiment Videos

Last Updated: Jun 13, 2026

3D-Neuronavigation In Vivo Through a Patient's Brain During a Spontaneous Migraine Headache

3D-Neuronavigation In Vivo Through a Patient's Brain During a Spontaneous Migraine Headache

Published on: June 2, 2014

Dural Stimulation and Periorbital von Frey Testing in Mice As a Preclinical Model of Headache

Dural Stimulation and Periorbital von Frey Testing in Mice As a Preclinical Model of Headache

Published on: July 29, 2021

Comparison of CA in CH with other headache disorders like migraine.

Main Results:

Some studies indicate CA occurs in a significant portion of CH patients, while others do not.
CA in CH presents with rapid onset and termination, differing from migraine.
CA in CH is prevalent in trigeminal areas but can extend to cervical regions.

Conclusions:

The pathophysiology of CA in CH requires further investigation.
The relationship between CH subtypes (episodic vs. chronic) and CA is unclear.
Understanding CA mechanisms in CH is crucial for its clinical management.