Advances in pediatric neurovirology
Related Experiment Video
Updated: Jun 13, 2026

Intracerebroventricular and Intravascular Injection of Viral Particles and Fluorescent Microbeads into the Neonatal Brain
Published on: July 24, 2016
1Department of Neurosciences and Pediatrics, University of California, 9500 Gilman Drive Box 0935, San Diego, CA 92093, USA. jrcrawford@ucsd.edu
Abstract:
Viral infections of the pediatric central nervous system (CNS) encompass a broad spectrum of both perinatally and postnatally acquired diseases with potentially devastating effects on the developing brain. In children, viral infections have been associated with chronic encephalopathy, encephalitis, demyelinating disease, tumors, and epilepsy. Older diagnostic techniques of biopsy, viral culture, electron microscopy, gel-based polymerase chain reaction (PCR), and viral titer quantification are being replaced with more rapid, sensitive, and specific real-time and microarray-based PCR technologies. Advances in neuroimaging technologies have provided for earlier recognition of CNS injury without elucidation of specific viral etiology. Although the mainstay therapy of many pediatric neurovirologic diseases, aside from HIV, includes intravenous acyclovir, much work is being done to develop novel antiviral immunotherapies aimed at both treating and preventing pediatric CNS viral disease.
More Related Videos
10:15Intracerebroventricular Viral Injection of the Neonatal Mouse Brain for Persistent and Widespread Neuronal Transduction
Published on: September 15, 2014
07:27Targeting the Corticospinal Tract in Neonatal Rats with a Double-Viral Vector using Combined Brain and Spine Surgery
Published on: June 30, 2021
Related Concept Videos
Arboviral Encephalitis
Encephalitis ll: Pathophysiology
Poliomyelitis
Microorganisms in Medicine and Therapeutics
Pharmacokinetics in Pediatric Patients: Drug Excretion
Encephalitis l: Introduction