Role of C-reactive protein in contributing to increased cardiovascular risk in metabolic syndrome
Sridevi Devaraj1, Simona Valleggi, David Siegel
1University of California Davis Medical Center, Sacramento, CA 95817, USA.
Abstract:
Metabolic syndrome is associated with increased propensity for diabetes and cardiovascular disease. Low-grade inflammation is characteristic of metabolic syndrome. C-reactive protein, the best characterized biomarker of inflammation, is also an independent predictor of future cardiovascular events. This review outlines the role of high-sensitivity C-reactive protein in contributing to increased cardiovascular risk in metabolic syndrome by inducing endothelial cell dysfunction and activating monocytes.
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