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New technologies personalize diagnostics and therapeutics

Robert S Rosenson1

  • 1Mount Sinai Heart, Mount Sinai School of Medicine, One Gustave Levy Place, New York, NY 10029-6574, USA. robert.rosenson@mssm.edu

Current Atherosclerosis Reports
|April 29, 2010
PubMed

Insights

Atherosclerotic cardiovascular disease is a major health issue. Advanced

Area of Science:

  • Cardiovascular Medicine
  • Genomics
  • Proteomics
  • Metabolomics

Background:

  • Atherosclerotic cardiovascular disease (ASCVD) is a primary cause of death and disability.
  • Current strategies include lifestyle changes and medications, but many patients still experience events.
  • Gaps exist in identifying high-risk individuals and managing those with suboptimal biomarker levels.

Purpose of the Study:

  • To explore the potential of multi-omics approaches.
  • To enhance understanding of atherosclerosis.
  • To enable personalized diagnostics and therapeutics for cardiovascular disease.

Main Methods:

  • Review of current therapeutic lifestyle changes and pharmacotherapy.
  • Analysis of the role of genomics, proteomics, and metabolomics.
  • Focus on personalized approaches to cardiovascular disease management.

Main Results:

  • Guideline-directed strategies are not always sufficient.
  • Many individuals remain at risk despite optimal biomarker levels.
  • Multi-omics data offer new insights into atherosclerosis.

Conclusions:

  • Genomics, proteomics, and metabolomics can improve atherosclerosis understanding.
  • These 'omics' fields facilitate personalized diagnostic and therapeutic strategies.
  • Advancing personalized medicine is key to reducing cardiovascular morbidity and mortality.

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