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Proteomic and metabolomic profiles in atherothrombotic vascular disease
Roxana Martinez-Pinna1, Coral Barbas, Luis Miguel Blanco-Colio
1Vascular Research Laboratory, Instituto de Investigacion Sanitaria, Fundación Jimenez Diaz, Autonoma University, Av. Reyes Católicos 2, 28040, Madrid, Spain.
Insights
Proteomics and metabolomics offer new ways to understand atherothrombosis, a major cause of death. These advanced techniques help identify biomarkers for personalized medicine and better treatment strategies.
Area of Science:
- Cardiovascular Research
- Biomarker Discovery
- Systems Biology
Background:
- Atherothrombosis is a leading cause of death, driven by complex processes like oxidative stress and inflammation.
- Understanding these multifactorial mechanisms is crucial for developing new diagnostic and prognostic tools.
- Current knowledge gaps necessitate novel technologies for analyzing cellular and molecular pathways.
Purpose of the Study:
- To review recent advances in applying proteomic and metabolomic techniques to atherothrombosis research.
- To highlight the utility of these high-throughput methods in studying disease mechanisms.
- To explore their potential in identifying novel biomarkers for atherothrombosis.
Main Methods:
- Review of recent studies utilizing proteomic and metabolomic approaches.
- Analysis of data from platelets, red blood cells, polymorphonuclear cells, tissues, and plasma.
- Focus on high-throughput technologies for molecular and cellular process analysis.
Main Results:
- Proteomics and metabolomics provide insights into cellular and molecular events in atherothrombosis.
- These techniques have been applied to various biological samples, including blood cells and plasma.
- Recent studies demonstrate the potential for identifying key players in disease progression.
Conclusions:
- Proteomic and metabolomic techniques are powerful tools for studying atherothrombosis.
- These high-throughput methods facilitate the discovery of diagnostic and prognostic biomarkers.
- Integrating these technologies with systems biology and imaging will advance personalized medicine for atherothrombosis.
Abstract:
Atherothrombosis remains a major cause of morbidity and mortality in the western world. The underlying processes associated with clinical expression of atherothrombosis include oxidative stress and proteolysis in relation to neovascularisation and intraplaque hemorrhages, leading to immuno-inflammatory response, cell death, and extracellular matrix breakdown. The complex biological multifactorial nature of atherothrombosis requires the development of novel technologies that allow the analysis of cellular and molecular processes responsible for the transition to disease phenotypes and the discovery of new diagnostic and prognostic biomarkers. In the present article, we have reviewed recent advances in the application of proteomic and metabolomic techniques to the study of atherothrombosis. We have focused on recent studies analyzing cells involved in hemo-thrombus formation (platelets, red blood cells, and polymorphonuclear cells), as well as tissues, tissue-conditioned media, and plasma of atherothrombotic patients. In the future, the application of these high-throughput technologies, along with imaging techniques, in systems biology approaches will help to individualize medicine.
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