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Updated: Jun 13, 2026
09:43
An Efficient and Simple Method to Establish NK and T Cell Lines from Patients with Chronic Active Epstein-Barr Virus Infection
Published on: March 30, 2018
Epstein-Barr virus-related lymphoproliferative disorders
Nina D Wagner-Johnston1, Richard F Ambinder
1Sidney Kimmel Comprehensive Cancer Center at Johns Hopkins,1650 Orleans Street, CRB 389, Baltimore, MD 21231, USA.
Current Hematologic Malignancy Reports
|April 29, 2010
Summary
Epstein-Barr virus (EBV) causes lifelong infections and is linked to various lymphomas. This review updates knowledge on EBV-associated lymphoproliferative disorders, covering epidemiology, pathogenesis, and new treatments.
Area of Science:
- Virology
- Oncology
- Immunology
Background:
- Epstein-Barr virus (EBV) is a widespread gammaherpesvirus.
- EBV establishes lifelong, often asymptomatic, infections in human hosts.
- EBV is implicated in the development of numerous lymphomas and lymphoproliferative disorders.
Purpose of the Study:
- To provide an updated review of Epstein-Barr virus-associated lymphoproliferative disorders.
- To focus on the epidemiology, pathogenesis, and emerging therapeutic strategies for these conditions.
Main Methods:
- Comprehensive literature review of recent studies on EBV and lymphoproliferative disorders.
- Analysis of epidemiological data, pathogenetic mechanisms, and clinical trial outcomes.
- Synthesis of current knowledge and identification of novel treatment approaches.
Main Results:
- EBV's role in lymphomagenesis is complex, involving viral proteins and host immune responses.
- Epidemiological trends highlight specific populations at higher risk.
- Novel therapeutic strategies are being developed, targeting viral replication and host immune modulation.
Conclusions:
- EBV-associated lymphoproliferative disorders remain a significant clinical challenge.
- A deeper understanding of pathogenesis is crucial for developing effective treatments.
- Continued research into novel therapeutic approaches offers hope for improved patient outcomes.
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