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Related Concept Videos

Gene Therapy00:59

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Gene therapy is a technique where a gene is inserted into a person’s cells to prevent or treat a serious disease. The added gene may be a healthy version of the gene that is mutated in the patient, or it could be a different gene that inactivates or compensates for the patient’s disease-causing gene. For example, in patients with severe combined immunodeficiency (SCID) due to a mutation in the gene for the enzyme adenosine deaminase, a functioning version of the gene can be...
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Group Therapy01:26

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Group therapy is a sociocultural approach to psychological treatment, where individuals with shared psychological challenges come together under the guidance of a mental health professional. This therapeutic modality offers unique opportunities for individuals to connect, share, and grow within the context of a supportive group. By fostering mutual understanding and collaboration, group therapy can address a range of psychological concerns effectively, often complementing or surpassing the...
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Behavior Therapy01:22

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Behavior therapy incorporates diverse techniques rooted in classical conditioning principles to address maladaptive behaviors and anxiety disorders. These methods aim to reduce avoidance behaviors, foster adaptive coping mechanisms, and alter associations between stimuli and responses, making them effective in a wide range of therapeutic contexts.
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Drug Therapy01:28

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The advent of drug therapy has profoundly shaped modern mental health care, providing targeted treatments for a range of psychological disorders. Psychotherapeutic drugs, classified into antianxiety, antidepressant, and antipsychotic medications, address symptoms across anxiety disorders, mood disorders, and schizophrenia. While these medications have transformed patient outcomes, they require careful management due to their potential side effects and limitations.
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Cognitive Therapy01:25

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Cognitive therapy, pioneered by Aaron T. Beck in the 1960s, is a structured approach to addressing psychological distress by focusing on the influence of thoughts on emotions and behaviors. All cognitive therapies involve the basic assumption that human beings have control over their feelings, and that how individuals feel about something depends on how they think about it. Unlike psychoanalytic methods that delve into unconscious processes or humanistic approaches emphasizing...
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Electroconvulsive therapy (ECT), or shock therapy, remains a critical biomedical intervention for severe, treatment-resistant depression. While its origins can be traced back to Hippocrates' observations that malaria-induced convulsions alleviated mental illness, modern ECT has evolved significantly from its earlier, more primitive applications. First introduced in 1938 by Ugo Cerletti and his colleagues, ECT involves inducing controlled seizures using electrical currents. In its early...
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Antifibrotic therapies: will we ever get there?

Alexander James Thompson1, Keyur Patel

  • 1Division of Gastroenterology and Hepatology, Duke Clinical Research Institute, Duke University Medical Center, Durham, NC 27705, USA.

Current Gastroenterology Reports
|April 29, 2010
PubMed
Summary

Liver fibrosis is a dynamic process that can be reversed. This review highlights promising antifibrotic strategies for chronic liver injury, aiming to prevent cirrhosis and liver cancer.

Area of Science:

  • Hepatology
  • Fibrosis Research
  • Translational Medicine

Background:

  • Progressive hepatic fibrosis is a common outcome of chronic liver injury, potentially leading to cirrhosis, liver failure, and hepatocellular carcinoma.
  • Fibrosis is now understood as a dynamic and potentially reversible process before significant liver architectural damage occurs.
  • While curing underlying liver diseases is ideal, specific antifibrotic therapies are crucial as this is often not feasible.

Purpose of the Study:

  • To review current advancements in understanding liver fibrosis pathogenesis.
  • To highlight promising antifibrotic strategies for clinical development.
  • To address challenges in antifibrotic therapy development, including trial design and assessment.

Main Methods:

  • Review of current scientific literature on liver fibrosis.

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  • Analysis of novel therapeutic targets and their clinical development status.
  • Discussion of limitations in preclinical models and noninvasive fibrosis assessment.

    • Main Results:

    • Several novel therapeutic targets for liver fibrosis have been identified.
    • Clinical development of antifibrotic therapies has faced significant challenges and disappointments.
    • Difficulties in accurately assessing fibrosis noninvasively and the prolonged natural history of the disease complicate clinical trials.

    Conclusions:

    • Despite challenges, advances in understanding fibrosis offer potential for new treatments.
    • Developing effective antifibrotic therapies remains a critical unmet need in managing chronic liver diseases.
    • Focus on promising strategies is essential for future clinical success in combating liver fibrosis.