Occupational rhinitis and asthma: where do we stand, where do we go?
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Updated: Jun 13, 2026

Immunofluorescent Labeling in Nasal Mucosa Tissue Sections of Allergic Rhinitis Rats via Multicolor Immunoassay
Published on: September 22, 2023
Roberto Castano1, Jean-Luc Malo
1Department of Otolaryngology/Research Center, Hôpital du Sacré-Coeur de Montréal, 5400 Boulevard Gouin Ouest, J-3185, Montréal, Québec, H4J 1C5, Canada. roberto.castano@mail.mcgill.ca
Abstract:
This review provides an overview of current and emerging issues regarding occupational rhinitis (OR) and occupational asthma (OA), focusing on studies discussing concepts and results that are relevant to both diseases. OA and OR are conditions that affect the upper and lower airways, are characterized by reduced airway caliber and hyperresponsiveness and by inflammation, and are caused by agents present in the workplace. To explain disease expression, research is moving from the T-helper type 1/type 2 cells paradigm to consider the contribution of diverse alternative pathways such as neural inflammation, a dysfunctional epithelial barrier, and autoimmune mechanisms, among others. Objective assessment of OR and OA has been improved and tested for research and, currently, clinical application. Further developments in the field of OR are expected to lead to more generalized clinical applications, following the example of what has been achieved for OA.
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