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Impact of High-intensity Interval Exercise and Moderate-Intensity Continuous Exercise on the Cardiac Troponin T Level at an Early Stage of Training
07:40

Impact of High-intensity Interval Exercise and Moderate-Intensity Continuous Exercise on the Cardiac Troponin T Level at an Early Stage of Training

Published on: October 10, 2019

[Troponin release following exercise test in patients with stable angina pectoris - risk factors and prognostic

Piotr Kokowicz1, Sebastian Stec, Katarzyna Flasińska

  • 1Postgraduates Medical School, Warsaw, Poland. kokowicz@kkcmkp.pl

Kardiologia Polska
|April 29, 2010
PubMed

Insights

Troponin I (cTnI) release after exercise testing (ExT) in stable coronary artery disease (CAD) patients is linked to lower ejection fraction and high blood pressure. This cTnI increase does not predict future cardiac events or mortality.

Area of Science:

  • Cardiology
  • Clinical Diagnostics
  • Exercise Physiology

Background:

  • Cardiac troponin (cTn) elevation indicates myocardial injury from various causes.
  • Exercise testing (ExT) aids in predicting myocardial ischemia risk, particularly in multivessel coronary artery disease (CAD), but has limitations in sensitivity and specificity.

Purpose of the Study:

  • To investigate the causes of troponin I (cTnI) release following ExT.
  • To assess the clinical and prognostic significance of cTnI release in stable CAD patients undergoing elective coronary angiography (ANG).

Main Methods:

  • 118 stable CAD patients without systolic heart failure underwent baseline NT-proBNP, hsCRP, cTnI, and CK-MB measurements.
  • Maximal ExT was performed, followed by cTnI and CK-MB measurements at 12 and 24 hours.
  • Coronary angiography, echocardiography, and a mean 35.5-month follow-up were conducted.

Main Results:

  • cTnI elevation (≥0.14 ng/mL) occurred in 9% of patients 24 hours post-ExT.
  • Predictors of cTnI release included ejection fraction ≤50%, low physical activity, and peak systolic blood pressure >160 mm Hg.
  • Post-ExT cTnI increase did not correlate with multivessel CAD or adverse clinical events.

Conclusions:

  • cTnI release post-ExT in stable CAD is associated with reduced ejection fraction, low physical activity, and high peak systolic blood pressure.
  • Elevated cTnI after ExT in this cohort showed no correlation with coronary artery disease extent.
  • Post-ExT cTnI elevation had no prognostic value for future adverse cardiovascular events or mortality.
Abstract

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