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Cystic fibrosis (CF) is an autosomal recessive disorder that predominantly affects individuals of Northern European descent, occurring at a rate of 1 in 3500. It is caused by a genetic mutation in a gene on chromosome 7, most commonly the ΔF508 mutation, that codes for the cystic fibrosis transmembrane conductance regulator (CFTR) protein. This results in thicker mucus secretions and obstruction pathologies in multiple organs, including the lungs and sinuses.
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Improving services for cleft lip and palate. A work in progress.

B Shaw

    Community Dental Health
    |April 30, 2010
    PubMed
    Summary
    This summary is machine-generated.

    Cleft lip and palate is an overlooked orphan condition. Greater advocacy from patient organizations is needed for progress in public health and clinical care.

    Area of Science:

    • Medical Research
    • Public Health
    • Clinical Genetics

    Background:

    • Cleft lip and palate (CLP) is recognized as an orphan condition, impacting a specific patient population.

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  • CLP often falls outside the primary focus of various clinical disciplines, leading to fragmented care.
  • The condition is frequently overlooked by public health consultants and health commissioners.