Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

Hyperchloremia and negative anion gap associated with polymyxin B administration.

D T O'Connor, R A Stone

    Archives of Internal Medicine
    |March 1, 1978
    PubMed
    Summary

    Polymyxin B sulfate can cause electrolyte imbalances, including a high anion gap metabolic acidosis. These issues resolved after stopping the drug, indicating a link to its properties.

    Related Concept Videos

    You might also read

    Related Articles

    Articles linked to this work by shared authors, journal, and citation graph.

    Sort by
    Same author

    Visual conditions affecting eye growth alter diurnal levels of vitreous DOPAC.

    Experimental eye research·2020
    Same author

    The Presence of a High Peak Feature Within Low-Average Shear Stimuli Induces Quiescence in Venous Endothelial Cells.

    Annals of biomedical engineering·2019
    Same author

    Gene networks specific for innate immunity define post-traumatic stress disorder.

    Molecular psychiatry·2015
    Same author

    Some thoughts on the mechanical anatomy of the female pelvis.

    The Australian journal of physiotherapy·2014
    Same author

    3D optic disc reconstruction via a global fundus stereo algorithm.

    Annual International Conference of the IEEE Engineering in Medicine and Biology Society. IEEE Engineering in Medicine and Biology Society. Annual International Conference·2013
    Same author

    Associations between hepatocyte growth factor, c-Met, and basic fibroblast growth factor and survival in endometrial cancer patients.

    British journal of cancer·2012

    Area of Science:

    • Pharmacology
    • Nephrology
    • Critical Care Medicine

    Background:

    • Polymyxin B is a critical antibiotic for multidrug-resistant Gram-negative infections.
    • Electrolyte disturbances are potential adverse effects of certain medications.

    Observation:

    • A patient developed significant electrolyte abnormalities, including hyperkalemia and a high anion gap metabolic acidosis, during intravenous polymyxin B sulfate therapy.
    • These abnormalities were temporally associated with the drug administration.

    Findings:

    • Discontinuation of polymyxin B sulfate led to the resolution of the observed electrolyte abnormalities.
    • In vitro studies indicated that the polycationic nature of polymyxin B likely contributed to the electrolyte disturbances.

    Implications:

    • Clinicians should monitor electrolytes in patients receiving polymyxin B.
    • Understanding the mechanism of polymyxin B-induced electrolyte imbalance is crucial for patient safety and management.
    • Further research may explore strategies to mitigate these adverse effects.

    Related Experiment Videos