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Updated: Jun 13, 2026

Nanomechanics of Drug-target Interactions and Antibacterial Resistance Detection
Published on: October 25, 2013
Enantioanalysis of (-)butaclamol using vancomycin and teicoplanin as chiral selectors
Raluca-Ioana Stefan-van Staden1, Nontete Suzan Nhlapo, Jacobus Frederick van Staden
1National Institute of Research for Electrochemistry and Condensed Matter, Bucharest, Romania. iustinavanstaden@yahoo.com
Abstract:
Butaclamol is an antipsychotic drug used in the treatment of schizophrenia. The macrocyclic antibiotics, vancomycin and teicoplanin, are proposed as chiral selectors for the design of the enantioselective, potentiometric membrane electrodes (EPMEs) for the assay of (-)butaclamol. The slopes of the electrodes are near-Nernstian for the assay of (-) butaclamol with linear concentration ranges between 10(-10) and 10(-7) mol/L and between 10(-9) and 10(-7) mol/L for vancomycin and teicoplanin based EPMEs. Limits of detections varied. The electrodes were used reliably for the enantioanalysis of (-) butaclamol in serum samples.
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