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Dapsone for thrombocytopenic purpura related to human immunodeficiency virus infection
J M Durand1, P Lefèvre, P Hovette
1Clinique Médicale B, Pr M. Mongin, CHU Timone, Marseille, France.
The American Journal of Medicine
|June 1, 1991
Abstract
Purpose:
The purpose of this study was to determine the effect of dapsone on platelet count in patients with human immunodeficiency virus (HIV)-related autoimmune thrombocytopenia.
Patients And Methods:
Eleven patients with HIV-related thrombocytopenia received dapsone (50 to 125 mg/day) for 2 to 43 months. Patients with the acquired immunodeficiency syndrome were not enrolled.
Results:
Of the 11 patients, six developed platelet counts above 50 X 10(9)/L and did not require any other specific therapy. No significant side effects were observed.
Conclusion:
We conclude that dapsone may be effective in some patients with HIV-related thrombocytopenia.