Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

The chronic fatigue syndrome.

S D Shafran1

  • 1Division of Infectious Diseases, Walter C. MacKenzie Health Sciences Centre, University of Alberta, Edmonton, Canada.

The American Journal of Medicine
|June 1, 1991
PubMed
Summary
This summary is machine-generated.

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Response to Noe, Oldenbuettel and Jaeger.

HIV medicine·2019
Same author

Planning HIV therapy to prevent future comorbidities: patient years for tenofovir alafenamide.

HIV medicine·2019
Same author

Efficacy and safety results of patients with HCV genotype 2 or 3 infection treated with ombitasvir/paritaprevir/ritonavir and sofosbuvir with or without ribavirin (QUARTZ II-III).

Journal of viral hepatitis·2017
Same author

Live attenuated herpes zoster vaccine for HIV-infected adults.

HIV medicine·2015
Same author

Seroprevalence of HSV-1 and HSV-2 antibodies in Canadian women screened for enrolment in a herpes simplex virus vaccine trial.

International journal of STD & AIDS·2013
Same author

The cost of health care for AIDS patients in Saskatchewan.

The Canadian journal of infectious diseases = Journal canadien des maladies infectieuses·2012

Chronic Fatigue Syndrome (CFS) is a disabling condition affecting adults, predominantly women, with symptoms lasting over six months. Current research shows no definitive cause or proven effective treatment, highlighting the need for further investigation.

Area of Science:

  • Medical Research
  • Immunology
  • Neurology

Background:

  • Chronic Fatigue Syndrome (CFS) defined in 1988, characterized by disabling fatigue for at least 6 months.
  • Reported globally, primarily affecting women aged 20-50.
  • Etiology remains uncertain despite numerous investigations.

Purpose of the Study:

  • To review the current understanding of Chronic Fatigue Syndrome.
  • To analyze reported epidemiological data, potential causes, and clinical findings.
  • To assess the efficacy of treatments and long-term prognosis.

Main Methods:

  • Review of existing literature and case reports on CFS.
  • Analysis of epidemiological data regarding affected demographics.
  • Evaluation of immunological and physical findings in CFS patients.

Related Experiment Videos

Main Results:

  • No infectious agent causally linked to CFS.
  • Frequent but inconsistent minor immunologic aberrations noted.
  • Depression present in ~50% of patients, sometimes preceding fatigue.
  • No consistent evidence for myopathy or deconditioning.
  • No therapy proven effective in controlled trials; antidepressants not formally evaluated.

Conclusions:

  • CFS is a prolonged illness with significant morbidity but no mortality.
  • Further research into pathogenesis and treatment is essential.
  • Current understanding lacks definitive causal links or effective therapeutic strategies.