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Updated: Jun 13, 2026

Isolation and Flow Cytometric Analysis of Glioma-infiltrating Peripheral Blood Mononuclear Cells
Published on: November 28, 2015
Oncomodulatory mechanisms of human cytomegalovirus in gliomas
1Memorial Neuroscience Center, Memorial Hospital Jacksonville, Suite 355, Jacksonville, Florida 32216, USA. kbarami@yahoo.com
Abstract:
Human cytomegalovirus (HCMV), a widespread beta-herpes virus, infects a high percentage of high grade gliomas. Although HCMV is not recognized as an oncogenic virus, it might increase the malignancy of the infected cell by disrupting cellular pathways involved in the cell cycle, apoptosis, angiogenesis, cell invasion and the host immune response. This article reviews the recent evidence of the modulatory effects of HCMV infection leading to the malignant progression of gliomas and explores novel therapeutic targets against such lethal tumors.
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