Search research articles

ABOUT JoVE

Overview Leadership Blog JoVE Help Center

AUTHORS

Publishing Process Editorial Board Scope & Policies Peer Review FAQ Submit

LIBRARIANS

Testimonials Subscriptions Access Resources Library Advisory Board FAQ

RESEARCH

JoVE Journal Methods Collections JoVE Encyclopedia of Experiments Archive

EDUCATION

JoVE Core JoVE Business JoVE Science Education JoVE Lab Manual Faculty Resource Center Faculty Site

Terms & Conditions of Use

Related Concept Videos

Mesenchymal Stem Cells

Mesenchymal Stem Cells

Mesenchymal stem cells (MSCs) are adult stem cells that can differentiate into most connective tissue cell types, except for hematopoietic cells, depending upon the source of MSCs. For example, bone-marrow-derived MSCs (BM-MSCs) can differentiate into osteocytes, hepatocytes, and pancreatic and neuronal cells. MSCs can be isolated from various sources such as bone marrow, placenta, adipose tissue, teeth, and Wharton’s jelly, a gelatinous substance in the umbilical cord. The ease of their access...

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by

Same author

Introduction to the 60th Annual Thomas L. Petty Aspen Lung Conference. Environment and Global Lung Health: Exposure, Susceptibility, and Intervention.

Annals of the American Thoracic Society·2018

Same author

Cigarette smoke represses the innate immune response to asbestos.

Physiological reports·2015

Same author

Development and application of a rat PBPK model to elucidate kidney and liver effects induced by ETBE and tert-butanol.

Toxicology and applied pharmacology·2015

Same author

Evaluation of anti-nuclear antibodies and kidney pathology in Lewis rats following exposure to Libby amphibole asbestos.

Journal of immunotoxicology·2012

Same author

Effects of Libby amphibole asbestos exposure on two models of arthritis in the Lewis rat.

Journal of toxicology and environmental health. Part A·2012

Same author

Chronic treatment in vivo with β-adrenoceptor agonists induces dysfunction of airway β(2) -adrenoceptors and exacerbates lung inflammation in mice.

British journal of pharmacology·2011

Search research articles

Related Experiment Video

Updated: Jun 13, 2026

Isolation of CD146+ Resident Lung Mesenchymal Stromal Cells from Rat Lungs

Isolation of CD146⁺ Resident Lung Mesenchymal Stromal Cells from Rat Lungs

Published on: June 17, 2016

Mesenchymal stem cells modulate lung injury.

Arnold R Brody¹, Keith D Salazar, Susan M Lankford

¹Department of Molecular Biomedical Sciences, North Carolina State University, 4700 Hillsborough Street, Raleigh, NC 27606, USA. arbrody@ncsu.edu

Proceedings of the American Thoracic Society

|April 30, 2010

Summary

Mesenchymal stem cells (MSCs) show potential for lung injury treatment. Research is exploring optimal conditions for MSC therapy to maximize benefits and avoid harm in lung diseases.

More Related Videos

Induction of Mouse Lung Injury by Endotracheal Injection of Bleomycin

Induction of Mouse Lung Injury by Endotracheal Injection of Bleomycin

Published on: April 30, 2019

Isolation & Characterization of Hoechstlow CD45negative Mouse Lung Mesenchymal Stem Cells

Isolation & Characterization of Hoechst^low CD45^negative Mouse Lung Mesenchymal Stem Cells

Published on: October 26, 2011

Related Experiment Videos

Last Updated: Jun 13, 2026

Isolation of CD146+ Resident Lung Mesenchymal Stromal Cells from Rat Lungs

Isolation of CD146⁺ Resident Lung Mesenchymal Stromal Cells from Rat Lungs

Published on: June 17, 2016

Induction of Mouse Lung Injury by Endotracheal Injection of Bleomycin

Induction of Mouse Lung Injury by Endotracheal Injection of Bleomycin

Published on: April 30, 2019

Isolation & Characterization of Hoechstlow CD45negative Mouse Lung Mesenchymal Stem Cells

Isolation & Characterization of Hoechst^low CD45^negative Mouse Lung Mesenchymal Stem Cells

Published on: October 26, 2011

Area of Science:

Regenerative Medicine
Cell Biology
Pulmonary Medicine

Background:

Mesenchymal stem cells (MSCs) possess multipotent differentiation capabilities.
MSCs are accessible from bone marrow and umbilical cord blood, allowing for propagation and clinical use.
Preclinical studies show MSCs engraft in the lung and ameliorate acute and chronic lung injury models.

Purpose of the Study:

To review the in vitro biology of MSCs.
To summarize MSC applications in animal models of lung injury.
To discuss the therapeutic potential and challenges of MSCs for lung diseases.

Main Methods:

Review of existing literature on MSC biology and preclinical studies.
Analysis of MSC engraftment and therapeutic effects in lung injury models.
Exploration of MSC potential in lung cancer and interstitial fibrosis.

Main Results:

MSCs differentiate into various mesenchymal and epithelial cell types.
Demonstrated efficacy of MSCs in models of LPS-, bleomycin-, and asbestos-induced lung injury.
Uncertainty remains regarding optimal conditions for MSC administration and potential for exacerbation.

Conclusions:

MSCs hold promise for treating lung diseases, including cancer and fibrosis.
Further research is needed to determine optimal therapeutic strategies for MSC application.
Understanding the conditions for MSC use is crucial to harness their full therapeutic potential while mitigating risks.