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Outcome of Iranian children with mild post streptococcal glomerulonephritis

Alaleh Gheissari1, Taj Saadat Adjodani, Maryam Hashemi

  • 1Pediatric Nephrology Department, St. Alzahra Hospital, Isfahan University of Medical Sciences, Isfahan, Iran. gheisari@med.mui.ac.ir

Saudi Journal of Kidney Diseases and Transplantation : an Official Publication of the Saudi Center for Organ Transplantation, Saudi Arabia
|April 30, 2010
PubMed

Insights

Even mild acute post streptococcal glomerulonephritis (APSGN) can cause long-term kidney issues. Rising diastolic blood pressure may signal early renal impairment in children with APSGN.

Area of Science:

  • Pediatric Nephrology
  • Glomerular Diseases

Background:

  • Acute post-streptococcal glomerulonephritis (APSGN) is a common kidney disease in children.
  • Long-term outcomes of mild APSGN require further investigation.

Purpose of the Study:

  • To evaluate the long-term renal outcomes in children with mild APSGN.
  • To identify potential early clinical signs of renal impairment in pediatric APSGN.

Main Methods:

  • Retrospective study of 27 children with mild APSGN hospitalized between 1993-1998.
  • Patients were divided into two groups based on follow-up duration: 4 years (Group A, n=15) and 8 years (Group B, n=12).
  • Assessed glomerular filtration rate (GFR), systolic, and diastolic blood pressure.

Main Results:

  • No significant difference in mean GFR or systolic blood pressure between the two groups.
  • Mean diastolic blood pressure was significantly higher in Group B (8-year follow-up) compared to Group A (4-year follow-up).
  • Mild APSGN was associated with some degree of renal impairment over time.

Conclusions:

  • Mild APSGN can lead to persistent renal impairment.
  • Elevated diastolic blood pressure may serve as an early indicator of renal impairment in pediatric APSGN patients.

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